Energy-sensing and signaling by AMP-activated protein kinase in skeletal muscle.

  title={Energy-sensing and signaling by AMP-activated protein kinase in skeletal muscle.},
  author={W. Winder},
  journal={Journal of applied physiology},
  volume={91 3},
  • W. Winder
  • Published 2001
  • Biology, Medicine
  • Journal of applied physiology
  • AMP-activated protein kinase (AMPK) is emerging as an important energy-sensing/signaling system in skeletal muscle. This kinase is activated allosterically by 5'-AMP and inhibited allosterically by creatine phosphate. Phosphorylation of AMPK by an upstream kinase, AMPK kinase (also activated allosterically by 5'-AMP), results in activation. It is activated in both rat and human muscle in response to muscle contraction, the extent of activation depending on work rate and muscle glycogen… CONTINUE READING
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