Energy restriction lowers the expression of genes linked to inflammation, the cytoskeleton, the extracellular matrix, and angiogenesis in mouse adipose tissue.

@article{Higami2006EnergyRL,
  title={Energy restriction lowers the expression of genes linked to inflammation, the cytoskeleton, the extracellular matrix, and angiogenesis in mouse adipose tissue.},
  author={Yoshikazu Higami and Jamie L Barger and Grier P. Page and David B. Allison and Steven R. Smith and Tomas A. Prolla and Richard Weindruch},
  journal={The Journal of nutrition},
  year={2006},
  volume={136 2},
  pages={343-52}
}
Using high-density oligonucleotide microarrays, we examined the actions of energy restriction (ER) on the expression of >11,000 genes in epididymal white adipose tissue (WAT) of 10- to 11-mo-old male C57Bl6 mice. Four groups were studied: controls not subjected to food restriction (CO), food-restricted 18 h before being killed (FR), short-term ER for 23 d (SER), and long-term ER for 9 mo (LER). As we reported previously, compared with CO mice, FR and SER minimally influenced the gene expression… CONTINUE READING