Energy production, intracellular amino acid pools, and protein synthesis in chronic renal disease.

@article{Metcoff1989EnergyPI,
  title={Energy production, intracellular amino acid pools, and protein synthesis in chronic renal disease.},
  author={Jack Metcoff and Peter T. Furst and Karl Scharer and G. Distler and Rainer K. Weber and Jasmin Mangold and T A Graser and G{\"u}nther Pfaff and D Schonberg},
  journal={Journal of the American College of Nutrition},
  year={1989},
  volume={8 4},
  pages={271-84}
}
Intracellular glycolytic regulating enzyme activities, pyruvate kinase (PK) and phosphofructokinase (PFK), adenylate kinase (AK), energy charge (Ech), free amino acids (ICAA), and protein synthesis (PS) were measured in polymorphonuclear leukocytes--used as a cell model--in 62 adults and 12 children with chronic renal failure, and 66 normal adults and 21 children as comparison controls. In normal subjects, children had significantly lower enzyme activities and cell amino acid levels but similar… CONTINUE READING