Energy metabolism transition in multi-cellular human tumor spheroids.

@article{RodrguezEnrquez2008EnergyMT,
  title={Energy metabolism transition in multi-cellular human tumor spheroids.},
  author={Sara Rodr{\'i}guez-Enr{\'i}quez and Juan Carlos Gallardo-P{\'e}rez and Alejandro Avil{\'e}s-Salas and {\'A}lvaro Mar{\'i}n-Hern{\'a}ndez and Liliana Carre{\~n}o-Fuentes and Vilma Maldonado-Lagunas and Rafael Moreno-S{\'a}nchez},
  journal={Journal of cellular physiology},
  year={2008},
  volume={216 1},
  pages={189-97}
}
It is thought that glycolysis is the predominant energy pathway in cancer, particularly in solid and poorly vascularized tumors where hypoxic regions develop. To evaluate whether glycolysis does effectively predominate for ATP supply and to identify the underlying biochemical mechanisms, the glycolytic and oxidative phosphorylation (OxPhos) fluxes, ATP/ADP ratio, phosphorylation potential, and expression and activity of relevant energy metabolism enzymes were determined in multi-cellular tumor… CONTINUE READING
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