Energy metabolism targeted drugs synergize with photodynamic therapy to potentiate breast cancer cell death.

@article{Feng2014EnergyMT,
  title={Energy metabolism targeted drugs synergize with photodynamic therapy to potentiate breast cancer cell death.},
  author={Xiaolan Feng and Yi Irvette Zhang and Pan Wang and Quanhong Liu and Xiaobing Wang},
  journal={Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology},
  year={2014},
  volume={13 12},
  pages={1793-803}
}
Malignant cells are highly dependent on aerobic glycolysis, which differs significantly from normal cells (the Warburg effect). Interference of this metabolic process has been considered as an innovative method for developing selective cancer therapy. A recent study demonstrated that the glycolysis inhibitor 2-deoxyglucose (2-DG) can potentiate PDT efficacy, whereas the possible mechanisms have not been carefully investigated. This study firstly proved the general potentiation of PDT efficacy… CONTINUE READING
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