Energy metabolism inhibition impairs amyloid precursor protein secretion from Alzheimer's fibroblasts.

@article{Gasparini1999EnergyMI,
  title={Energy metabolism inhibition impairs amyloid precursor protein secretion from Alzheimer's fibroblasts.},
  author={Leonardo C. Gasparini and Luisa Benussi and Angelo Bianchetti and Giuliano Binetti and Daniela Curti and Stefano Govoni and Stefania Moraschi and Marco Racchi and Marco Trabucchi},
  journal={Neuroscience letters},
  year={1999},
  volume={263 2-3},
  pages={197-200}
}
The present study investigates the influence of aglycemia and sodium azide (a Cytochrome c Oxidase inhibitor) on sAPP secretion from skin fibroblasts derived from sporadic AD patients and control subjects. Aglycemia reduced sAPP release in the medium of both AD and control fibroblasts to a similar extent after 2 h incubation. Treatment for 2 h with increasing azide concentrations (1 microM-100 mM) under glucose deprivation did not significantly affect sAPP secretion from control fibroblasts… CONTINUE READING