Energy metabolism in tumor cells

  title={Energy metabolism in tumor cells},
  author={Rafael Moreno-S{\'a}nchez and Sara Rodr{\'i}guez-Enr{\'i}quez and {\'A}lvaro Mar{\'i}n-Hern{\'a}ndez and Emma Saavedra},
  journal={The FEBS Journal},
In early studies on energy metabolism of tumor cells, it was proposed that the enhanced glycolysis was induced by a decreased oxidative phosphorylation. Since then it has been indiscriminately applied to all types of tumor cells that the ATP supply is mainly or only provided by glycolysis, without an appropriate experimental evaluation. In this review, the different genetic and biochemical mechanisms by which tumor cells achieve an enhanced glycolytic flux are analyzed. Furthermore, the… 
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