Energy metabolism in hypoxia: reinterpreting some features of muscle physiology on molecular grounds

@article{Cerretelli2010EnergyMI,
  title={Energy metabolism in hypoxia: reinterpreting some features of muscle physiology on molecular grounds},
  author={Paolo Cerretelli and Cecilia Gelfi},
  journal={European Journal of Applied Physiology},
  year={2010},
  volume={111},
  pages={421-432}
}
An holistic approach for interpreting classical data on the adaptation of the animal and, particularly, of the human body to hypoxic stress was promoted by the discovery of HIF-1, the “master regulator” of cell hypoxic signaling. Mitochondrial production of ROS stabilizes the O2-regulated HIF-1α subunit of the HIF-1 dimer promoting transaction functions in a large number of potential target genes, activating transcription of sequences into RNA and, eventually, protein production. The aim of the… CONTINUE READING