Energy metabolism and energy-sensing pathways in mammalian embryonic and adult stem cell fate
- BiologyJournal of Cell Science
Determining how energy metabolism regulates stem cell fate should shed light on the decline in tissue regeneration that occurs during aging and facilitate the development of therapies for degenerative or metabolic diseases.
Mitochondrial Metabolism-Mediated Regulation of Adult Neurogenesis
- BiologyBrain plasticity
Recent findings describing stage-specific modulations of mitochondrial metabolism within the adult NSC lineage are discussed, emphasizing its importance for NSC self-renewal, proliferation of neural stem and progenitor cells, cell fate decisions, and differentiation and maturation of newborn neurons.
Thyroid hormone regulation of neural stem cell fate: From development to ageing
- BiologyActa physiologica
It is concluded that, together, TH and cellular metabolism regulate optimal brain formation, maturation and function from early foetal life to adult in vertebrate species.
Introduction to embryonic and adult neural stem cells: from the metabolic circuits of the niches to the metabolome
Metabolomics has provided new insight into the biology that drives the phenotype of stem cells. During the recent years, metabolic circuits of embryonic and neural stem cells (NSCs) have been better…
Insulin and IGF receptor signalling in neural-stem-cell homeostasis
- BiologyNature Reviews Endocrinology
Emerging data on the functions of IGF-II and IGF and/or insulin receptor signalling in the context of NSC regulation in the SVZ and SGZ are discussed and a model is proposed in which the choroid plexus is a major component of the NSC niche.
Metabolic regulation and its molecular mechanisms in various stem cell functions.
- BiologyCurrent stem cell research & therapy
Current advances in metabolic research that have revealed functional roles for mitochondrial oxidative phosphorylation, anaerobic glycolysis, and oxidative stress during the self-renewal, differentiation and aging of various adult stem cell types are reviewed.
Adult neural stem cell fate is determined by thyroid hormone activation of mitochondrial metabolism
- BiologyMolecular metabolism
Magnesium regulates neural stem cell proliferation in the mouse hippocampus by altering mitochondrial function
- BiologyCell biology international
It is determined that magnesium, a key nutrient in cellular energy metabolism, affects neural stem cell (NSC) proliferation in cells derived from the embryonic hippocampus by influencing mitochondrial function.
Nutrients, neurogenesis and brain ageing: From disease mechanisms to therapeutic opportunities
- BiologyBiochemical pharmacology
SHOWING 1-10 OF 383 REFERENCES
The role of oxygen in regulating neural stem cells in development and disease
- BiologyJournal of cellular physiology
It is suggested that O2 response is central to the normal architecture and dynamics of NSC regulation and in the etiology and treatment of brain diseases.
FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis.
- BiologyCell stem cell
Retinoic acid and neurotrophins collaborate to regulate neurogenesis in adult-derived neural stem cell cultures.
- BiologyJournal of neurobiology
Hippocampus-derived stem cell clones were used to examine the effects of retinoic acid on neuronal differentiation, and RA first promoted the acquisition of a neuronal fate, and NTs subsequently enhanced maturation by way of RA-dependent expression of the Trk receptors.
Redox regulation of precursor cell function: insights and paradoxes.
- BiologyAntioxidants & redox signaling
Findings indicate that intracellular redox state is utilized by the organism as a means of regulating the balance between progenitor cell division and differentiation, and Paradoxically, the results obtained through studies on the oligodendrocyte lineage are precisely the opposite of what might be predicted.
Notch signalling regulates stem cell numbers in vitro and in vivo
Notch receptor activation induces the expression of the specific target genes hairy and enhancer of split 3 and Sonic hedgehog through rapid activation of cytoplasmic signals, including the serine/threonine kinase Akt, the transcription factor STAT3 and mammalian target of rapamycin, and thereby promotes the survival of neural stem cells.
A role for adult TLX-positive neural stem cells in learning and behaviour
It is demonstrated that TLX (also called NR2E1) regulates adult neural stem cell proliferation in a cell-autonomous manner by controlling a defined genetic network implicated in cell proliferation and growth.
AMP-activated protein kinase phosphorylates retinoblastoma protein to control mammalian brain development.
- BiologyDevelopmental cell
PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry.
- BiologyProceedings of the National Academy of Sciences of the United States of America
The results demonstrate an enhanced self-renewal capacity and G(0)-G(1) cell cycle entry and decreased growth factor dependency of Pten null neural/stem progenitor cells and loss of PTEN leads to cell physiological changes, which collectively are sufficient to increase the pool of self- renewable neural stem cells and promote their escape from the homeostatic mechanisms of proliferation control.
Autophagic Death of Adult Hippocampal Neural Stem Cells Following Insulin Withdrawal
- Biology, MedicineStem cells
It is demonstrated that Hippocampal neural (HCN) stem cells undergo a caspase‐independent, autophagic cell death following insulin withdrawal, which may provide novel strategies to improve the survival rate of transplanted stem cells for treatment of neurodegenerative diseases.