Energy metabolism and energy-sensing pathways in mammalian embryonic and adult stem cell fate.

@article{Rafalski2012EnergyMA,
  title={Energy metabolism and energy-sensing pathways in mammalian embryonic and adult stem cell fate.},
  author={Victoria A. Rafalski and Elena Mancini and Anne Brunet},
  journal={Journal of cell science},
  year={2012},
  volume={125 Pt 23},
  pages={5597-608}
}
Metabolism is influenced by age, food intake, and conditions such as diabetes and obesity. How do physiological or pathological metabolic changes influence stem cells, which are crucial for tissue homeostasis? This Commentary reviews recent evidence that stem cells have different metabolic demands than differentiated cells, and that the molecular mechanisms that control stem cell self-renewal and differentiation are functionally connected to the metabolic state of the cell and the surrounding… CONTINUE READING
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