Energy linked modifications of the radiation response in a human cerebral glioma cell line.

@article{Dwarkanath1989EnergyLM,
  title={Energy linked modifications of the radiation response in a human cerebral glioma cell line.},
  author={B S Dwarkanath and Vibha Kumari Jain},
  journal={International journal of radiation oncology, biology, physics},
  year={1989},
  volume={17 5},
  pages={1033-40}
}
Effects of cellular energy metabolism on the radiation response of a cell derived from a human cerebral glioma have been studied under conditions of energy limitation produced by the presence of inhibitors of respiratory metabolism (KCN) and glycolysis (glucose analogues such as 2-DG, 5-TG, and 3-0-MG). Radiation 60Co induced DNA repair (Unscheduled DNA Synthesis) and micronuclei formation were studied as measures of radiation response. Glycolysis (lactate production) and levels of adenine and… CONTINUE READING

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