Energy landscapes of receptor–ligand bonds explored with dynamic force spectroscopy

@article{Merkel1999EnergyLO,
  title={Energy landscapes of receptor–ligand bonds explored with dynamic force spectroscopy},
  author={Rudolf Merkel and Pierre Nassoy and Alethea Leung and Ken Ritchie and Evan Evans},
  journal={Nature},
  year={1999},
  volume={397},
  pages={50-53}
}
Atomic force microscopy (AFM), has been used to measure the strength of bonds between biological receptor molecules and their ligands. But for weak noncovalent bonds, a dynamic spectrum of bond strengths is predicted as the loading rate is altered, with the measured strength being governed by the prominent barriers traversed in the energy landscape along the force-driven bond-dissociation pathway. In other words, the pioneering early AFM measurements represent only a single point in a… CONTINUE READING
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