Energy landscape of the ribosomal decoding center.

  title={Energy landscape of the ribosomal decoding center.},
  author={Karissa Y. Sanbonmatsu},
  volume={88 8},
The ribosome decodes the genetic information that resides in nucleic acids. A key component of the decoding mechanism is a conformational switch in the decoding center of the small ribosomal subunit discovered in high-resolution X-ray crystallography studies. It is known that small subunit nucleotides A1492 and A1493 flip out of helix 44 upon transfer RNA (tRNA) binding; however, the operation principles of this switch remain unknown. Replica molecular dynamics simulations reveal a low free… CONTINUE READING