Energy expenditure and substrate metabolism in ethanol-induced liver cirrhosis.

@article{Mller1991EnergyEA,
  title={Energy expenditure and substrate metabolism in ethanol-induced liver cirrhosis.},
  author={Manfred M{\"u}ller and A Fenk and H. U. Lautz and Oliver Selberg and Helmuth Canzler and Hans J. Balks and Alexander Von Zur M{\"u}hlen and Edgar Schmidt and Friedrich Werner Schmidt},
  journal={The American journal of physiology},
  year={1991},
  volume={260 3 Pt 1},
  pages={
          E338-44
        }
}
Energy expenditure and substrate metabolism were investigated in 10 patients with alcoholic liver cirrhosis (EtOH-Ci) and 10 healthy controls (C). Resting metabolic rate (RMR) varied from 1,269 to 2,467 kcal/day in C and from 1,228 to 2,098 kcal/day in EtOH-Ci. RMR was significantly related to fat-free mass (FFM) in both groups, but EtOH-Ci decreased FFM and increased RMR when expressed per kilogram FFM (+33%). Glucose intolerance, hyperinsulinemia, and a decreased C-peptide-to-insulin ratio… CONTINUE READING
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