Energy-efficient action potentials in hippocampal mossy fibers.

  title={Energy-efficient action potentials in hippocampal mossy fibers.},
  author={Henrik Alle and Arnd Roth and J{\"o}rg R. P. Geiger},
  volume={325 5946},
Action potentials in nonmyelinated axons are considered to contribute substantially to activity-dependent brain metabolism. Here we show that fast Na+ current decay and delayed K+ current onset during action potentials in nonmyelinated mossy fibers of the rat hippocampus minimize the overlap of their respective ion fluxes. This results in total Na+ influx and associated energy demand per action potential of only 1.3 times the theoretical minimum, in contrast to the factor of 4 used in previous… CONTINUE READING
Highly Influential
This paper has highly influenced 25 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 165 extracted citations

The energetics of CNS white matter.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2012
View 12 Excerpts
Highly Influenced

Updated energy budgets for neural computation in the neocortex and cerebellum.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism • 2012
View 18 Excerpts
Highly Influenced

Fast sodium channel gating supports localized and efficient axonal action potential initiation.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2010
View 6 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 29 references

Blood Flow Metab

S Mangia
Blood Flow Metab • 2009

Brief. Funct. Genomics Proteomics

C B Moens, T M Donn, E R Wolf-Saxon, T P Ma
Brief. Funct. Genomics Proteomics • 2008


J Svaren, D Meijer
Glia • 2008

J. Neurosci

Y Yu, Y Shu, D A Mccormick
J. Neurosci • 2008


N K Logothetis
Nature • 2008

Nat. Rev. Neurosci

B P Bean
Nat. Rev. Neurosci • 2007

PLoS Comput. Biol

A A Faisal, S B Laughlin
PLoS Comput. Biol • 2007

Dev. Biol

H M Pogoda
Dev. Biol • 2006

Genes Cells

T Moriguchi
Genes Cells • 2004


T K Bjarnadottir
Genomics • 2004

Similar Papers

Loading similar papers…