Energy-efficient action potentials in hippocampal mossy fibers.

@article{Alle2009EnergyefficientAP,
  title={Energy-efficient action potentials in hippocampal mossy fibers.},
  author={Henrik Alle and Arnd Roth and J{\"o}rg R. P. Geiger},
  journal={Science},
  year={2009},
  volume={325 5946},
  pages={1405-8}
}
Action potentials in nonmyelinated axons are considered to contribute substantially to activity-dependent brain metabolism. Here we show that fast Na+ current decay and delayed K+ current onset during action potentials in nonmyelinated mossy fibers of the rat hippocampus minimize the overlap of their respective ion fluxes. This results in total Na+ influx and associated energy demand per action potential of only 1.3 times the theoretical minimum, in contrast to the factor of 4 used in previous… CONTINUE READING
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