Energy dispersive X-ray analysis of titanium dioxide nanoparticle distribution after intravenous and subcutaneous injection in mice.

@article{Patri2009EnergyDX,
  title={Energy dispersive X-ray analysis of titanium dioxide nanoparticle distribution after intravenous and subcutaneous injection in mice.},
  author={Anil K. Patri and Thomas H. Umbreit and Jiwen Zheng and Kunio Nagashima and Peter L. Goering and Sabine Francke-Carroll and Edward Gordon and James Weaver and Terry Miller and Nakissa K Sadrieh and Scott P. McNeil and Melvin E Stratmeyer},
  journal={Journal of applied toxicology : JAT},
  year={2009},
  volume={29 8},
  pages={662-72}
}
In an effort to understand the disposition and toxicokinetics of nanoscale materials, we used EDS (energy dispersive X-ray spectroscopy) to detect and map the distribution of titanium dioxide (TiO2) in tissue sections from mice following either subcutaneous (s.c.) or intravenous (i.v.) injection. TiO2 nanoparticles were administered at a dose of 560 mg/kg (i.v.) or 5600 mg/kg (s.c.) to Balb/c female mice on two consecutive days. Tissues (liver, kidney, lung, heart, spleen, and brain) were… CONTINUE READING
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