Energy coupling in Saccharomyces cerevisiae: selected opportunities for metabolic engineering.

@article{Kok2012EnergyCI,
  title={Energy coupling in Saccharomyces cerevisiae: selected opportunities for metabolic engineering.},
  author={Stefan de Kok and Barbara U. Kozak and Jack T. Pronk and Antonius J. A. van Maris},
  journal={FEMS yeast research},
  year={2012},
  volume={12 4},
  pages={387-97}
}
Free-energy (ATP) conservation during product formation is crucial for the maximum product yield that can be obtained, but often overlooked in metabolic engineering strategies. Product pathways that do not yield ATP or even demand input of free energy (ATP) require an additional pathway to supply the ATP needed for product formation, cellular maintenance, and/or growth. On the other hand, product pathways with a high ATP yield may result in excess biomass formation at the expense of the product… CONTINUE READING