Energy calculations on aspartic proteinases: human renin, endothiapepsin and its complex with an angiotensinogen fragment analogue, H-142.

@article{Hemmings1985EnergyCO,
  title={Energy calculations on aspartic proteinases: human renin, endothiapepsin and its complex with an angiotensinogen fragment analogue, H-142.},
  author={Andrew M. Hemmings and S. I. Foundling and Bancinyane Lynn Sibanda and Steve P. Wood and Laurence H. Pearl and Tom L. Blundell},
  journal={Biochemical Society transactions},
  year={1985},
  volume={13 6},
  pages={1036-41}
}
The rational design of inhibitors of human renin for the treatment of hypertension depends on a detailed knowledge of the renin-angiotensinogen transition-state complex. Direct determination of the three-dimensional structure of complexes of human renin with transition state analogues is not possible until large quantities of human renin are made available… CONTINUE READING