Energy Transduction and Alternating Access of the Mammalian ABC Transporter P-glycoprotein

@inproceedings{Verhalen2017EnergyTA,
  title={Energy Transduction and Alternating Access of the Mammalian ABC Transporter P-glycoprotein},
  author={Brandy Verhalen and Reza Dastvan and Sundarapandian Thangapandian and Yelena Peskova and Hanane A. Koteiche and Robert K. Nakamoto and Emad Tajkhorshid and Hassane S. Mchaourab},
  booktitle={Nature},
  year={2017}
}
ATP binding cassette (ABC) transporters of the exporter class harness the energy of ATP hydrolysis in the nucleotide-binding domains (NBDs) to power the energetically uphill efflux of substrates by a dedicated transmembrane domain (TMD). Although numerous investigations have described the mechanism of ATP hydrolysis and defined the architecture of ABC exporters, a detailed structural dynamic understanding of the transduction of ATP energy to the work of substrate translocation remains elusive… CONTINUE READING
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