Energy Metabolism during Apoptosis

@article{Garland1997EnergyMD,
  title={Energy Metabolism during Apoptosis},
  author={J. Garland and A. Halestrap},
  journal={The Journal of Biological Chemistry},
  year={1997},
  volume={272},
  pages={4680 - 4688}
}
We have investigated cell metabolism during apoptosis in the murine interleukin-3 (IL-3)-dependent cell line Bo and two derivative clones (B14 and B15) overexpressing human bcl-2a. On removal of IL-3, Bo cells underwent apoptosis within 8 h, whereas B14 and B15 cells were resistant for at least 24 h. Metabolically, Bo, B14, and B15 cells were indistinguishable from each other. All were insensitive to mitochondrial poisons, derived ATP entirely by glycolysis, and maintained similar mitochondrial… Expand
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References

SHOWING 1-10 OF 44 REFERENCES
Distinct mechanisms may account for the growth-promoting activity of interleukin 3 on cells of lymphoid and myeloid origin.
  • R. Palacios, J. Garland
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1984
...
1
2
3
4
5
...