Energized mitochondria increase the dynamic range over which inositol 1,4,5‐trisphosphate activates store‐operated calcium influx

@article{Gilabert2001EnergizedMI,
  title={Energized mitochondria increase the dynamic range over which inositol 1,4,5‐trisphosphate activates store‐operated calcium influx},
  author={J. Gilabert and D. Bakowski and A. Parekh},
  journal={The EMBO Journal},
  year={2001},
  volume={20}
}
  • J. Gilabert, D. Bakowski, A. Parekh
  • Published 2001
  • Biology, Medicine
  • The EMBO Journal
  • In eukaryotic cells, activation of cell surface receptors that couple to the phosphoinositide pathway evokes a biphasic increase in intracellular free Ca2+ concentration: an initial transient phase reflecting Ca2+ release from intracellular stores, followed by a plateau phase due to Ca2+ influx. A major component of this Ca2+ influx is store‐dependent and often can be measured directly as the Ca2+ release‐activated Ca2+ current (ICRAC). Under physiological conditions of weak intracellular Ca2… CONTINUE READING
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