Energization-dependent endogenous activation of proton conductance in skeletal muscle mitochondria

@inproceedings{Parker2008EnergizationdependentEA,
  title={Energization-dependent endogenous activation of proton conductance in skeletal muscle mitochondria},
  author={N. Parker and Charles Affourtit and Antonio Vidal-Puig and Martin D. Brand},
  booktitle={The Biochemical journal},
  year={2008}
}
Leak of protons into the mitochondrial matrix during substrate oxidation partially uncouples electron transport from phosphorylation of ADP, but the functions and source of basal and inducible proton leak in vivo remain controversial. In the present study we describe an endogenous activation of proton conductance in mitochondria isolated from rat and mouse skeletal muscle following addition of respiratory substrate. This endogenous activation increased with time, required a high membrane… CONTINUE READING