Energetics of gramicidin hybrid channel formation as a test for structural equivalence. Side-chain substitutions in the native sequence.

@article{Durkin1990EnergeticsOG,
  title={Energetics of gramicidin hybrid channel formation as a test for structural equivalence. Side-chain substitutions in the native sequence.},
  author={John T. Durkin and Roger E Koeppe and Olaf S Andersen},
  journal={Journal of molecular biology},
  year={1990},
  volume={211 1},
  pages={221-34}
}
To determine whether amino acid side-chain substitutions in linear gramicidins after the structure of membrane-spanning channels formed by the modified peptides, we have developed a quantitative measure of structural equivalence of the peptide backbone among gramicidin channels based on functional (single-channel) measurements. The experiments exploit the fact that gramicidin channels are symmetrical dimers, and that channels formed by different gramicidin analogues can be distinguished on the… CONTINUE READING

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