Energetics of Shaker K channels block by inactivation peptides

  title={Energetics of Shaker K channels block by inactivation peptides},
  author={Ruth D Murrell-Lagnado and Richard W. Aldrich},
  journal={The Journal of General Physiology},
  pages={977 - 1003}
A synthetic peptide of the NH2-terminal inactivation domain of the ShB channel blocks Shaker channels which have an NH2-terminal deletion and mimics many of the characteristics of the intramolecular inactivation reaction. To investigate the role of electrostatic interactions in both peptide block and the inactivation process we measured the kinetics of block of macroscopic currents recorded from the intact ShB channel, and from ShB delta 6-46 channels in the presence of peptides, at different… CONTINUE READING


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Fast inactivation by the ball peptide in Shaker B K channels is highly temperature dependent

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1 Excerpt

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