Energetics and specificity of Rat DNA polymerase beta interactions with template-primer and gapped DNA substrates.

Abstract

Interactions between rat polymerase beta (pol beta) and the template-primer, as well as gapped DNAs, were studied using the quantitative fluorescence titration technique. Stoichiometries of rat pol beta complexes with DNA substrates are much higher than stoichiometries predicted by the structures of co-crystals. The data can be understood in the context of… (More)

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