Energetic optimization of ion conduction rate by the K+ selectivity filter

@article{MoraisCabral2001EnergeticOO,
  title={Energetic optimization of ion conduction rate by the K+ selectivity filter},
  author={J. H. Morais-Cabral and Y. Zhou and R. MacKinnon},
  journal={Nature},
  year={2001},
  volume={414},
  pages={37-42}
}
  • J. H. Morais-Cabral, Y. Zhou, R. MacKinnon
  • Published 2001
  • Chemistry, Medicine
  • Nature
  • The K+ selectivity filter catalyses the dehydration, transfer and rehydration of a K+ ion in about ten nanoseconds. This physical process is central to the production of electrical signals in biology. Here we show how nearly diffusion-limited rates are achieved, by analysing ion conduction and the corresponding crystallographic ion distribution in the selectivity filter of the KcsA K+ channel. Measurements with K+ and its slightly larger analogue, Rb+, lead us to conclude that the selectivity… CONTINUE READING
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    References

    SHOWING 1-10 OF 32 REFERENCES
    KcsA: it's a potassium channel.
    • 272
    • PDF
    Potassium blocks barium permeation through a calcium-activated potassium channel
    • 212
    • PDF
    Potassium flux ratio in voltage-clamped squid giant axons
    • 77
    • PDF