Energetic optimization of ion conduction rate by the K+ selectivity filter

  title={Energetic optimization of ion conduction rate by the K+ selectivity filter},
  author={J. H. Morais-Cabral and Y. Zhou and R. MacKinnon},
  • J. H. Morais-Cabral, Y. Zhou, R. MacKinnon
  • Published 2001
  • Chemistry, Medicine
  • Nature
  • The K+ selectivity filter catalyses the dehydration, transfer and rehydration of a K+ ion in about ten nanoseconds. This physical process is central to the production of electrical signals in biology. Here we show how nearly diffusion-limited rates are achieved, by analysing ion conduction and the corresponding crystallographic ion distribution in the selectivity filter of the KcsA K+ channel. Measurements with K+ and its slightly larger analogue, Rb+, lead us to conclude that the selectivity… CONTINUE READING
    674 Citations

    Paper Mentions

    Selectivity and permeation of alkali metal ions in K+-channels.
    • 23
    Multi-ion free energy landscapes underscore the microscopic mechanism of ion selectivity in the KcsA channel.
    • 21
    Kinetic modeling of ion conduction in KcsA potassium channel.
    • 8
    • PDF
    Insights into the mechanisms of K+ permeation in K+-channels from computer simulations.
    • PDF
    Modeling permeation energetics in the KcsA potassium channel.
    • 44
    Energetics of Multi-Ion Conduction Pathways in Potassium Ion Channels
    • 30


    KcsA: it's a potassium channel.
    • 272
    • PDF
    Potassium blocks barium permeation through a calcium-activated potassium channel
    • 212
    • PDF
    Potassium flux ratio in voltage-clamped squid giant axons
    • 77
    • PDF