Energetic effects of caffeine in face of retarded Na+/Ca2+ exchange in isolated, arrested guinea pig hearts.

@article{Hanley1994EnergeticEO,
  title={Energetic effects of caffeine in face of retarded Na+/Ca2+ exchange in isolated, arrested guinea pig hearts.},
  author={Peter J. Hanley and P. J. Cooper and Denis Scott Loiselle},
  journal={The American journal of physiology},
  year={1994},
  volume={267 5 Pt 2},
  pages={H1663-9}
}
The effects of caffeine, a widely used pharmacological tool for releasing Ca2+ from the sarcoplasmic reticulum (SR), on the resting rate of oxygen consumption and left ventricular diastolic pressure development of isolated, KCl-arrested, guinea pig hearts was examined. Caffeine (10 mmol/l) had no effect on either the rate of oxygen consumption or left ventricular pressure development. However, when Ca2+ extrusion via the Na+/Ca2+ exchanger was retarded, whether by reducing the external Na… CONTINUE READING

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