Energetic contribution of solvent-exposed ion pairs to alpha-helix structure.

  title={Energetic contribution of solvent-exposed ion pairs to alpha-helix structure.},
  author={Pingchiang Lyu and Paul J. Gans and Neville R. Kallenbach},
  journal={Journal of molecular biology},
  volume={223 1},
Understanding the role of amino acid side-chain interactions in forming secondary structure in proteins is useful for deciphering how proteins fold and for predicting folded structures of proteins from their sequence. Analysis of the secondary structure as a function of pH in two designed synthetic peptides with identical composition but different sequences, affords a quantitative estimate of the free energy contribution of a single ion pair to the stability of an isolated alpha-helix. One… CONTINUE READING

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