Energetic and cell membrane metabolic products in patients with primary insomnia: a 31-phosphorus magnetic resonance spectroscopy study at 4 tesla.

@article{Harper2013EnergeticAC,
  title={Energetic and cell membrane metabolic products in patients with primary insomnia: a 31-phosphorus magnetic resonance spectroscopy study at 4 tesla.},
  author={David G C Harper and David T. Plante and J. Eric Jensen and Caitlin Ravichandran and Orfeu M. Buxton and Kathleen L Benson and Shawn P O'Connor and Perry F. Renshaw and John W. Winkelman},
  journal={Sleep},
  year={2013},
  volume={36 4},
  pages={493-500}
}
STUDY OBJECTIVES Primary insomnia (PI) is a sleep disorder characterized by difficulty with sleep initiation, maintenance, and/or the experience of nonrestorative sleep combined with a subsequent impairment of daytime functioning. The hyperarousal hypothesis has emerged as the leading candidate to explain insomnia symptoms in the absence of specific mental, physical, or substance-related causes. We hypothesized that the cellular energetic metabolites, including beta nucleoside triphosphate… CONTINUE READING
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