Enduring suppression of hippocampal long-term potentiation following traumatic brain injury in rat.

@article{Miyazaki1992EnduringSO,
  title={Enduring suppression of hippocampal long-term potentiation following traumatic brain injury in rat.},
  author={Shiniti Miyazaki and Yoichi Katayama and Bruce G. Lyeth and Larry W. Jenkins and Douglas S. Dewitt and Stephen J. Goldberg and P G Newlon and Ronald L. Hayes},
  journal={Brain research},
  year={1992},
  volume={585 1-2},
  pages={335-9}
}
This study investigated changes in synaptic responses (population spike and population EPSP) of CA1 pyramidal cells of the rat hippocampus to stimulation of the Schaffer collateral/commissural pathways 2-3 h after traumatic brain injury (TBI). TBI was induced by a fluid percussion pulse delivered to the parietal epidural space resulting in loss of righting responses for 4.90-8.98 min. Prior to tetanic stimulation, changes observed after the injury included: (1) decreases in population spikes… CONTINUE READING

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