Enduring increases in anxiety-like behavior and rapid nucleus accumbens dopamine signaling in socially isolated rats.

@article{Yorgason2013EnduringII,
  title={Enduring increases in anxiety-like behavior and rapid nucleus accumbens dopamine signaling in socially isolated rats.},
  author={Jordan T Yorgason and Rodrigo A Espa{\~n}a and Joanne K. Konstantopoulos and Jeffrey L. Weiner and Sara R Jones},
  journal={The European journal of neuroscience},
  year={2013},
  volume={37 6},
  pages={1022-31}
}
Social isolation (SI) rearing, a model of early life stress, results in profound behavioral alterations, including increased anxiety-like behavior, impaired sensorimotor gating and increased self-administration of addictive substances. These changes are accompanied by alterations in mesolimbic dopamine function, such as increased dopamine and metabolite tissue content, increased dopamine responses to cues and psychostimulants, and increased dopamine neuron burst firing. Using voltammetric… CONTINUE READING
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