Enduring consequences of early-life infection on glial and neural cell genesis within cognitive regions of the brain.

@article{Bland2010EnduringCO,
  title={Enduring consequences of early-life infection on glial and neural cell genesis within cognitive regions of the brain.},
  author={Sondra T. Bland and Jacob T. Beckley and Sarah Young and Verne Tsang and Linda R. Watkins and Steven F. Maier and Staci D. Bilbo},
  journal={Brain, behavior, and immunity},
  year={2010},
  volume={24 3},
  pages={329-38}
}
Systemic infection with Escherichia coli on postnatal day (P) 4 in rats results in significantly altered brain cytokine responses and behavioral changes in adulthood, but only in response to a subsequent immune challenge with lipopolysaccharide [LPS]. The basis for these changes may be long-term changes in glial cell function. We assessed glial and neural cell genesis in the hippocampus, parietal cortex (PAR), and prefrontal cortex (PFC), in neonates just after the infection, as well as in… CONTINUE READING
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