Endurance training-induced accumulation of muscle triglycerides is coupled to upregulation of stearoyl-CoA desaturase 1.

@article{Dobrzyn2010EnduranceTA,
  title={Endurance training-induced accumulation of muscle triglycerides is coupled to upregulation of stearoyl-CoA desaturase 1.},
  author={Pawel Dobrzyn and Aleksandra Pyrkowska and Magdalena Jazurek and Konrad Szymanski and J{\'o}zef Langfort and Agnieszka Dobrzyń},
  journal={Journal of applied physiology},
  year={2010},
  volume={109 6},
  pages={1653-61}
}
Stearoyl-CoA desaturase (SCD), a rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids, has recently been shown to be a critical control point in regulation of liver and skeletal muscle metabolism. Herein, we demonstrate that endurance training significantly increases both SCD1 mRNA and protein levels in the soleus muscle, whereas it does not affect SCD1 expression in the EDL muscle and liver. Desaturation index (18:1Δ9/18:0 ratio), an indirect indicator of SCD1 activity, was… CONTINUE READING

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