Endurance training in obese humans improves glucose tolerance and mitochondrial fatty acid oxidation and alters muscle lipid content.

  title={Endurance training in obese humans improves glucose tolerance and mitochondrial fatty acid oxidation and alters muscle lipid content.},
  author={Clinton R. Bruce and A. Brianne Thrush and Valerie A Mertz and Véronic Bézaire and Adrian Chabowski and George J. F. Heigenhauser and David J. Dyck},
  journal={American journal of physiology. Endocrinology and metabolism},
  volume={291 1},
Muscle fatty acid (FA) metabolism is impaired in obesity and insulin resistance, reflected by reduced rates of FA oxidation and accumulation of lipids. It has been suggested that interventions that increase FA oxidation may enhance insulin action by reducing these lipid pools. Here, we examined the effect of endurance training on rates of mitochondrial FA oxidation, the activity of carnitine palmitoyltransferase I (CPT I), and the lipid content in muscle of obese individuals and related these… 

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