Endpoint measures in the mdx mouse relevant for muscular dystrophy pre-clinical studies.

@article{Kobayashi2012EndpointMI,
  title={Endpoint measures in the mdx mouse relevant for muscular dystrophy pre-clinical studies.},
  author={Yvonne Monique Kobayashi and Erik P. Rader and Robert W. Crawford and Kevin P Campbell},
  journal={Neuromuscular disorders : NMD},
  year={2012},
  volume={22 1},
  pages={34-42}
}
Loss of mobility influences the quality of life for patients with neuromuscular diseases. Common measures of mobility and chronic muscle damage are the six-minute walk test and serum creatine kinase. Despite extensive pre-clinical studies of therapeutic approaches, characterization of these measures is incomplete. To address this, a six-minute ambulation assay, serum creatine kinase, and myoglobinuria were investigated for the mdx mouse, a dystrophinopathy mouse model commonly used in pre… CONTINUE READING
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Current status of pharmaceu tical and genetic therapetuic approac hes to treat DMD

  • C Pichavant, A Aartsma-R us, PR Clemens
  • Mol Ther
  • 2011
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