Endplate denervation correlates with Nogo-A muscle expression in amyotrophic lateral sclerosis patients

@inproceedings{Bruneteau2015EndplateDC,
  title={Endplate denervation correlates with Nogo-A muscle expression in amyotrophic lateral sclerosis patients},
  author={Ga{\"e}lle Bruneteau and St{\'e}phanie Bauch{\'e} and Jose Luis Gonzalez de Aguilar and Guy Brochier and Nathalie Mandjee and Marie-Laure Tanguy and Ghulam Hussain and Anthony B{\'e}hin and Fr{\'e}d{\'e}ric Khiami and El-hadi Sariali and Caroline Hell-Remy and François Salachas and Pierre-François Pradat and Lucette Lacomblez and Sarah{\'i} Nicole and Bertrand Fontaine and Michel Fardeau and J. Photographer Loeffler and Vincent Meininger and Emmanuel Fournier and Jeanine Koenig and Daniel Hantaı̈},
  booktitle={Annals of clinical and translational neurology},
  year={2015}
}
OBJECTIVE Data from mouse models of amyotrophic lateral sclerosis (ALS) suggest early morphological changes in neuromuscular junctions (NMJs), with loss of nerve-muscle contact. Overexpression of the neurite outgrowth inhibitor Nogo-A in muscle may play a role in this loss of endplate innervation. METHODS We used confocal and electron microscopy to study the structure of the NMJs in muscle samples collected from nine ALS patients (five early-stage patients and four long-term survivors). We… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 17 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 37 REFERENCES

Early and selective loss of neuromuscular synapse subtypes with low sprouting competence in motoneuron diseases.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2000
VIEW 11 EXCERPTS
HIGHLY INFLUENTIAL

El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis.

  • Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases
  • 2000
VIEW 11 EXCERPTS
HIGHLY INFLUENTIAL