Endozepine stupor. Recurring stupor linked to endozepine-4 accumulation.

  title={Endozepine stupor. Recurring stupor linked to endozepine-4 accumulation.},
  author={Elio Lugaresi and Pasquale Montagna and Paolo Tinuper and Guiseppe Plazzi and Roberto Gallassi and Theresa C. Wang and Sanford P. Markey and Jeffrey D Rothstein},
  journal={Brain : a journal of neurology},
  volume={121 ( Pt 1)},
Recurring stupor can be caused by repeated metabolic, toxic or structural brain disturbances. Recently, cases of recurring stupor, with fast EEG activity were shown to display increased endogenous benzodiazepine-like activity during the episodes of stupor. Patients with recurring stupor underwent extensive metabolic and toxicologic screening, EEG and brain imaging. Endozepines and exogenously administered benzodiazepines were assayed in plasma and CSF by means of mass spectrometry. Flumazenil… CONTINUE READING


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Endozepines: non-benzodiazepine endogenous allosteric modulators of GABA A receptors

  • JD Rothstein, A. Guidotti
  • The diagnosis of stupor and coma
  • 1993
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