Endozepine/diazepam binding inhibitor in adrenocortical and Leydig cell lines: absence of hormonal regulation.

@article{Brown1992EndozepinediazepamBI,
  title={Endozepine/diazepam binding inhibitor in adrenocortical and Leydig cell lines: absence of hormonal regulation.},
  author={Anne Sutton Brown and P. F. Hall and Mohammed Shoyab and Vassilios Papadopoulos},
  journal={Molecular and cellular endocrinology},
  year={1992},
  volume={83 1},
  pages={1-9}
}
One of the many effects which have been attributed to the peptide endozepine/diazepam binding inhibitor (Ep/DBI) is the stimulation of adrenocortical and testicular Leydig cell mitochondrial steroidogenesis. We have used two cell lines (Y-1 mouse adrenal cell tumour and MA-10 mouse Leydig cell tumour), both of which exhibit hormone stimulated steroid production, to investigate the role of Ep/DBI in acute hormone stimulated steroidogenesis. The time course of incorporation of 35S-translabel into… CONTINUE READING