Endovascular trophoblast invasion, spiral artery remodelling and uteroplacental haemodynamics in a transgenic rat model of pre-eclampsia.

@article{Geusens2008EndovascularTI,
  title={Endovascular trophoblast invasion, spiral artery remodelling and uteroplacental haemodynamics in a transgenic rat model of pre-eclampsia.},
  author={Nele Geusens and S Verlohren and Cath{\'e}rine Luyten and Marschall Taube and L. Hering and Lisbeth Vercruysse and Myriam Hanssens and Joachim Wolfram Dudenhausen and Ralf Dechend and Robert Pijnenborg},
  journal={Placenta},
  year={2008},
  volume={29 7},
  pages={
          614-23
        }
}
The aim of the present study was to evaluate the depth of endovascular trophoblast invasion and associated remodelling of spiral arteries in a transgenic model of pre-eclampsia in the rat, a species showing a comparable deep invasion during normal pregnancy as the human. Pre-eclamptic (PE) transgenic rats (TGR) (hAngiotensinogen female x hRenin male) and non-PE reversely mated (RM) TGR rats were compared to normal Sprague-Dawley rats (C). Day 18 implantation sites were collected and the… CONTINUE READING
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