Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials

@article{Goyal2016EndovascularTA,
  title={Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials},
  author={Mayank Goyal and Bijoy K. Menon and Wim H. van Zwam and Diederik W. J. Dippel and Peter J. Mitchell and Andrew M. Demchuk and Antoni D{\'a}valos and Charles B.L.M. Majoie and Aad van der Lugt and Maria A de Miquel and Geoffrey Alan Donnan and Yvo B.W.E.M. Roos and Alain Bonafe and R. Jahan and Hans Christoph Diener and Lucie A. van den Berg and Elad I. Levy and Olvert A. Berkhemer and Vitor Pereira and Jeremy L. Rempel and M{\'o}nica Mill{\'a}n and Stephen M. Davis and Daniel Roy and John M Thornton and Lu{\'i}s San Roman and Marc Rib{\'o} and Debbie Beumer and Bruce Stouch and Scott C. Brown and Bruce C.V. Campbell and Robert J. van Oostenbrugge and Jeffrey L. Saver and Michael D. Hill and Tudor G. Jovin},
  journal={The Lancet},
  year={2016},
  volume={387},
  pages={1723-1731}
}

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Endovascular thrombectomy should be strongly considered for all patients presenting within 6 hours of onset with a stroke affecting a proximal, anterior circulation vessel without a contraindication to ET.
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Among patients with anterior circulation stroke who could be treated within 8 hours after symptom onset, stent retriever thrombectomy reduced the severity of post-stroke disability and increased the rate of functional independence.
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Among patients with acute ischemic stroke, endovascular therapy with mechanical thrombectomy vs standard medical care with tPA was associated with improved functional outcomes and higher rates of angiographic revascularization, but no significant difference in symptomatic intracranial hemorrhage or all-cause mortality at 90 days.
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