Endotoxin uptake by S1 proximal tubular segment causes oxidative stress in the downstream S2 segment.

@article{Kalakeche2011EndotoxinUB,
  title={Endotoxin uptake by S1 proximal tubular segment causes oxidative stress in the downstream S2 segment.},
  author={Rabih Kalakeche and Takashi Hato and Georges J Rhodes and Kenneth W. Dunn and Tarek M. El-Achkar and Zoya Plotkin and Ruben M. Sandoval and Pierre C Dagher},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2011},
  volume={22 8},
  pages={1505-16}
}
Gram-negative sepsis carries high morbidity and mortality, especially when complicated by acute kidney injury (AKI). The mechanisms of AKI in sepsis remain poorly understood. Here we used intravital two-photon fluorescence microscopy to investigate the possibility of direct interactions between filtered endotoxin and tubular cells as a possible mechanism of AKI in sepsis. Using wild-type (WT), TLR4-knockout, and bone marrow chimeric mice, we found that endotoxin is readily filtered and… CONTINUE READING

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