Endotoxin treatment increases lung mitochondrial scavenging of extramitochondrial superoxide in hyperoxia-exposed rats.

Abstract

Mitochondria scavenge extramitochondrial superoxide anion via a respiration-dependent (i.e., non-enzymatic) mechanism. This study reports that hyperoxia exposure ( > 95 % O2 for 48h) reduced (P < 0.05) lung mitochondrial respiration-dependent superoxide scavenging by 56% compared to lung mitochondria from untreated control rats. In comparison, endotoxin… (More)

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