Endotoxin transiently inhibits protein synthesis through Akt and MAPK mediating pathways in C2C12 myotubes.

@article{Tarabees2011EndotoxinTI,
  title={Endotoxin transiently inhibits protein synthesis through Akt and MAPK mediating pathways in C2C12 myotubes.},
  author={Reda Z. Tarabees and Daniell B. Hill and Cyril Rauch and Paul Barrow and Paul Thomas Loughna},
  journal={American journal of physiology. Cell physiology},
  year={2011},
  volume={301 4},
  pages={C895-902}
}
In this study, the effect of lipopolysaccharide (LPS) on protein synthesis (PS) and intracellular signaling factors that regulate it have been investigated in C2C12 murine-derived myotubes. In particular, the role of Akt/mammalian target of rapamycin (mTOR) and the mitogen-activated protein kinases (MAPKs) [p38 and extracelluar regulated protein kinase (ERK1/2)] have been examined. The direct effect of LPS on PS was measured at 3 and 18 h. LPS significantly decreased PS at 3 h but not at the 18… CONTINUE READING