Endotoxin reduces specific pulmonary uptake of radiolabeled monoclonal antibody to angiotensin-converting enzyme.

@article{Muzykantov1991EndotoxinRS,
  title={Endotoxin reduces specific pulmonary uptake of radiolabeled monoclonal antibody to angiotensin-converting enzyme.},
  author={Vladimir R Muzykantov and E A Puchnina and Elena N. Atochina and H Hiemish and M. A. Slinkin and F. E. Meertsuk and Sergei M Danilov},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={1991},
  volume={32 3},
  pages={453-60}
}
The biodistribution of radiolabeled monoclonal antibody (Mab) to angiotensin-converting enzyme (ACE) was examined in normal and endotoxin-treated rats. Endotoxin administration at a dose of 4 mg/kg induced mild or middle pulmonary edema. The ACE activity in lung homogenate remained virtually unchanged, while the activity of serum ACE increased 15 hr after endotoxin infusion. In normal rats, anti-ACE Mab accumulates specifically in the lung after i.v. injection. Endotoxin injection induces… CONTINUE READING
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