Endotoxin promotes adverse effects of amorphous silica nanoparticles on lung epithelial cells in vitro.

  title={Endotoxin promotes adverse effects of amorphous silica nanoparticles on lung epithelial cells in vitro.},
  author={Yongli Shi and Santosh Yadav and Feng Wang and He Wang},
  journal={Journal of toxicology and environmental health. Part A},
  volume={73 11},
Amorphous silica engineered nanoparticles (ENP) are used for drug delivery and food additive under current regulations. Although the adverse effects of amorphous silica ENP may be negligible, contamination by bacterium products may enhance the toxic potential of these so-called safe products. Lipopolysaccharide (LPS), an endotoxin component generated by gram-negative bacteria, is a potential contaminant of amorphous silica ENP due to its ubiquitous presence in the environment. The combined… CONTINUE READING


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