Endotoxin produces a depressive-like episode in rats

@article{Yirmiya1996EndotoxinPA,
  title={Endotoxin produces a depressive-like episode in rats},
  author={Raz Yirmiya},
  journal={Brain Research},
  year={1996},
  volume={711},
  pages={163-174}
}
  • R. Yirmiya
  • Published 4 March 1996
  • Psychology, Biology
  • Brain Research
Systematic Analysis of the Cytokine and Anhedonia Response to Peripheral Lipopolysaccharide Administration in Rats
TLDR
The results do indicate that inflammation may cause depressive symptoms such as anhedonia, and using an optimized sucrose preference test (SPT) protocol, more elaborate rodent models can be developed to study the mechanisms underlying inflammation-associated depression in humans.
Inflammation-induced depression : Studying the role of proinflammatory cytokines in anhedonia
TLDR
An important role for increased monoamine transporter activity, and especially increased SERT activity, in inflammation-induced anhedonia is indicated, which should be given to the emotional status of patients with chronic inflammatory medical conditions and treat the psychic condition whenever necessary.
Effects of Antidepressant Drugs on the Behavioral and Physiological Responses to Lipopolysaccharide (LPS) in Rodents
Comparison of stress-induced and LPS-induced depressive-like behaviors and the alterations of central proinflammatory cytokines mRNA in rats.
TLDR
The findings from this study suggest that TNF-α may be a common risk factor for inflammation in depressive disorders.
Leptin Prevents Lipopolysaccharide-Induced Depressive-Like Behaviors in Mice: Involvement of Dopamine Receptors
TLDR
Leptin prevented the core behavioral alterations induced by LPS (despair-like behavior and anhedonia), without altering locomotion, and the results indicate that leptin has antidepressant-like effects in an inflammatory model of depression with the contribution, at least partial, of dopamine receptors.
Lipopolysaccharide-induced anhedonia is abolished in male serotonin transporter knockout rats: An intracranial self-stimulation study
Lipopolysaccharide-induced sickness behaviour evaluated in different models of anxiety and innate fear in rats.
TLDR
It is clearly showed that there are resting and alertness reactions induced by opposite neuroimmune mechanisms (neuroimmune bias) that could lead to anxiety behaviours, suggesting that misunderstanding data could occur when only few ethological variables or single doses of LPS are analysed.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 68 REFERENCES
Indomethacin prevents increased catecholamine turnover in rat brain following systemic endotoxin challenge
Animal model of depression: Pharmacological sensitivity of a hedonic deficit
  • R. Katz
  • Psychology, Biology
    Pharmacology Biochemistry and Behavior
  • 1982
Stress‐and Endotoxin‐Induced Increases in Brain Tryptophan and Serotonin Metabolism Depend on Sympathetic Nervous System Activity
TLDR
It is concluded that activation of the sympathetic nervous system is responsible for the stress‐related increases in brain tryptophan, probably by enabling increased brain tryPTophan uptake.
CHRONIC IMMUNE COMPLEX DISEASE: BEHAVIORAL AND IMMUNOLOGICAL CORRELATES
Using a fear avoidance paradigm, behavioral effects were seen in Sprague-Dawley rats in which chronic immune complex disease was induced. These effects were related to changes in urine protein that
...
1
2
3
4
5
...