Endotoxin-mediated endothelial cell injury and activation: role of soluble CD14.

  title={Endotoxin-mediated endothelial cell injury and activation: role of soluble CD14.},
  author={Moshe Arditi and Ji-Yan Zhou and R J D{\'o}rio and Guobin Rong and Sanna M. Goyert and Kwang Sik Kim},
  journal={Infection and immunity},
  volume={61 8},
Vascular endothelial cell (EC) injury by lipopolysaccharides (LPS) plays a major role in the pathogenesis of gram-negative bacterial sepsis and endotoxic shock. The studies described here were performed to define further the molecular mechanisms involved in the EC responses to LPS. We showed that serum was required for LPS-mediated cytotoxicity for bovine brain microvessel, pulmonary, and aortic ECs and that anti-human CD14 antibodies completely blocked LPS-mediated cytotoxicity for ECs in the… CONTINUE READING
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