Endotoxin inducible transcription is repressed in endotoxin tolerant cells.

@article{Yoza2000EndotoxinIT,
  title={Endotoxin inducible transcription is repressed in endotoxin tolerant cells.},
  author={Barbara K Yoza and Jean Y-Q Hu and Sue L. Cousart and Charles E McCall},
  journal={Shock},
  year={2000},
  volume={13 3},
  pages={
          236-43
        }
}
Stimulation of the human promonocytic cell line, THP-1, with endotoxin results in a rapid and transient increase in interleukin 1beta expression. Endotoxin pretreatment of THP-1 cells results in tolerance, characterized by decreased levels of endotoxin-induced interleukin 1beta expression due to decreased transcription of the interleukin 1beta gene. We hypothesized that tolerant cells could not activate transcription factors necessary to express the interleukin 1beta gene. This hypothesis was… CONTINUE READING
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