Endotoxin induces endothelial barrier dysfunction through protein tyrosine phosphorylation.

@article{Bannerman1997EndotoxinIE,
  title={Endotoxin induces endothelial barrier dysfunction through protein tyrosine phosphorylation.},
  author={Douglas D. Bannerman and Simeon E. Goldblum},
  journal={The American journal of physiology},
  year={1997},
  volume={273 1 Pt 1},
  pages={L217-26}
}
Bacterial lipopolysaccharide (LPS) induces actin reorganization, intercellular gap formation, and endothelial barrier dysfunction in vitro. We studied whether LPS-induced increments in 14C-labeled bovine serum albumin (BSA) flux across bovine pulmonary artery endothelial cell (EC) monolayers and actin depolymerization are mediated through protein tyrosine phosphorylation. Lysates from EC exposed to LPS derived from Escherichia coli 0111:B4 (100 ng/ml, 1 h) demonstrated increased tyrosine… CONTINUE READING

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