Endotoxin-induced uveitis is primarily dependent on radiation-resistant cells and on MyD88 but not TRIF.

@article{Kezic2011EndotoxininducedUI,
  title={Endotoxin-induced uveitis is primarily dependent on radiation-resistant cells and on MyD88 but not TRIF.},
  author={Jelena Marie Kezic and Shiv Taylor and Sanjay Gupta and Stephen R. Planck and H L Rosenzweig and James T. Rosenbaum},
  journal={Journal of leukocyte biology},
  year={2011},
  volume={90 2},
  pages={305-11}
}
TLR4 activation by LPS (endotoxin) is mediated by the MyD88 and TRIF intracellular signaling pathways. We determined the relative activation of these pathways in murine ocular tissue after LPS exposure. Additionally, we explored whether BM-derived or non-BM-derived cells were the major contributors to EIU. Mice deficient in TRIF or MyD88 and their congenic (WT) controls received 250 ng ultrapure LPS ivt at 0 h. Ocular inflammation was assessed by histological analysis at 4, 6, and 24 h, and… CONTINUE READING
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